Decoding the Scent.
Our philosophy is built on evidence. Here is the scientific validation behind peer-reviewed, PubMed-indexed research papers for Claspaw's formula.
A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects.
Key Finding:Inhalation of 1.0% bergamot essential oil activates a specific neural circuit (AON to ACC), significantly reducing anxiety-like behaviors.
Aromatic essential oils have been shown to relieve anxiety and enhance relaxation, although the neural circuits underlying these effects have remained unknown. Here, it is found that treatment with 1.0% bergamot essential oil (BEO) exerts anxiolytic-like effects through a neural circuit projecting from the anterior olfactory nucleus (AON) to the anterior cingulate cortex (ACC) in acute restraint stress model mice.
Relieving psychological stress and improving sleep quality by bergamot essential oil use before bedtime and upon awakening: A randomized crossover trial.
Key Finding:Bergamot essential oil significantly improved sleep quality, morning wakefulness, and reduced depression, anxiety, and stress scores.
This study aimed to verify whether bergamot essential oil use alleviates psychological stress due to the COVID-19 pandemic and improves sleep quality and morning wakefulness. A significant improvement was observed in 'sleepiness on rising,' 'refreshing on rising,' and 'sleep length' in the bergamot group. Additionally, a significant improvement was observed in depression, anxiety, and stress.
Using an aromatherapy intervention with outpatient treatment for substance use disorder.
Key Finding:Aroma-based intervention showed improvement in psychological variables with a significant increase in reported ease.
This study examined the effects of an aromatherapy intervention. Data analysis showed psychological variable improvement with a significant increase in ease reported. Results from this study provide data to support the feasibility and acceptability of using essential oil via inhalation to help this population.
Citrus Essential Oils in Aromatherapy: Therapeutic Effects and Mechanisms.
Key Finding:Citrus essential oils possess antioxidant properties and impart relaxing, calming, mood-uplifting effects, enhancing relaxation from stress and anxiety.
The citrus EOs possess a pleasant scent, and impart relaxing, calming, mood-uplifting, and cheer-enhancing effects. The diffusion creates a fresh feeling and enhances relaxation from stress and anxiety and helps uplifting mood and boosting emotional and physical energy. This review presents a comprehensive outlook on the composition, properties, characterization, and mechanism of action of the citrus EOs.
A review of citrus plants as functional foods and dietary supplements for human health.
Key Finding:Citrus species have shown anxiolytic, antimicrobial, and pain-alleviating effects in several meta-analyses and clinical trials.
Several meta-analyses and clinical trials have reported beneficial effects of citrus spices on a variety of cancer risks, cardiovascular risk factors, neurologic disorders, urinary tract conditions, and gastrointestinal tract conditions. They have shown anxiolytic, antimicrobial, and pain-alleviating effects.
Oral supplementation of Ocimum basilicum has the potential to improves the locomotory, exploratory, anxiolytic behavior.
Key Finding:Leaf extract of Ocimum basilicum improves neuromuscular co-ordination, exploratory behavior, and reduces anxiety in mice.
It was observed that 100 mg/ml solvent/kg body weight of leaf extract improves neuromuscular co-ordination and male albino mouse performance in open field, light dark box and during novel object test when compared with control group. We concluded that leaf extract has the potential to improve neuromuscular co-ordination, exploratory behavior, object recognition ability and transfer latency.
Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats.
Key Finding:Citrus aurantium (Neroli) flower extract significantly restored memory and learning impairments and reduced oxidative stress.
Administration of CA flower extract significantly restored memory and learning impairments induced by scopolamine in the passive avoidance test and also reduced escape latency during trial sessions in the Morris water maze test. Citrus aurantium flower extract significantly decreased the serum malondialdehyde (MDA) levels.
Comparison of the effect of lavender and bitter orange on anxiety in postmenopausal women.
Key Finding:Bitter orange (Neroli) significantly reduced mean state-anxiety and trait-anxiety scores compared with the control group.
Bitter orange significantly reduced the mean state-anxiety scores compared with the control group. Lavender significantly reduced the mean state-anxiety scores compared with the control group as well. The positive effect of bitter orange and lavender on anxiety in postmenopausal women suggests that they can be used to decrease anxiety in such women.
The effect of ylang oil and lemon oil inhalation on labor pain and anxiety pregnant women.
Key Finding:Ylang-ylang oil inhalation significantly reduced the perception of labor pain (p = 0.005) compared to the control group.
The mean pain scores at 5-7 cm dilatation in the intervention groups (lemon oil 6.90, ylang ylang oil, 7.30) were significantly lower than in the control group (9.20) (p = 0.005). It was found that aromatherapy applied by inhalation at labor reduced the perception of labor pain.
Ylang-ylang essential oil reduced neuropathic-pain and associated anxiety symptoms in mice.
Key Finding:Ylang-ylang essential oil reduced neuropathic pain and ameliorated pain-related anxiety symptoms by reducing neuroinflammation markers.
Oral administration of YEO (30 mg/kg) reduced SNI-induced neuropathic pain and ameliorates pain-related anxiety symptoms that appeared 28 days after surgery. YEO reduced the expression of MAPKs, NOS2, p-p65, markers of neuroinflammation, and promoted normalizing effect on neurotrophin levels (BDNF).
Ginger for treating nausea and vomiting: an overview of systematic reviews and meta-analyses.
Key Finding:Ginger is effective in managing chemotherapy-induced nausea and vomiting, and reduces postoperative nausea severity.
Our review's findings support ginger's effectiveness in managing chemotherapy-induced nausea and vomiting in cancer patients. It also reduces postoperative nausea and vomiting severity, decreasing the need for rescue antiemetics. Furthermore, ginger shows promise in alleviating pregnancy-related nausea and vomiting symptoms.
Effects of Ginger Intake on Chemotherapy-Induced Nausea and Vomiting: A Systematic Review.
Key Finding:Ginger supplementation showed a reduction in the incidence of acute nausea.
This study systematically reviewed 23 RCTs. The effects of ginger supplementation were compared to those of placebo or antiemetic agents. The results showed that the incidence of acute nausea was reduced with ginger supplementation.
Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome.
Key Finding:Peppermint oil was more efficacious than placebo for global IBS symptoms and abdominal pain.
Peppermint oil was more efficacious than placebo for global IBS symptoms (RR of not improving = 0.65), and abdominal pain (RR of abdominal pain not improving = 0.76). Peppermint oil was superior to placebo for the treatment of IBS.
The Effects of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients.
Key Finding:Peppermint oil significantly reduced the frequency of nausea, vomiting, retching and the severity of nausea.
The peppermint oil was significantly reduced the frequency of nausea, vomiting, retching and the severity of nausea in cancer patients undergoing chemotherapy. Therefore, usage of peppermint oil together with antiemetics after chemotherapy with moderate and low emetic risk may be recommended to cope with CINV.
Effects of aromatherapy on nausea and vomiting in patients with cancer: A systematic review.
Key Finding:Aromatherapy, particularly peppermint oil, reduced overall nausea and vomiting with significant efficacy.
Twenty-five RCTs across 10 articles revealed that aromatherapy reduced overall nausea and vomiting in patients with cancer with significant efficacy. Inhalation and massage yielded positive results, especially in chemotherapy-induced cases; peppermint oil was particularly successful.